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Cells in multicellular organisms rely on secreted ligands for development and morphogenesis. Several mechanisms modulate the availability and distribution of secreted ligands, determining their philadelphia pa escorts to al locally and at long range from their source.
One of these mechanisms is Dally-like protein Dlpa cell-surface glypican that escort agency nashville biphasic functions in Drosophila wing discs, promoting Wg aling at long-range from Wg source cells and inhibiting Wg aling near source cells. In the germarium at the tip of the ovary, Dlp promotes long-range distribution of Wg from cap cells to follicle stem cells.
However, the germarium also expresses other Wnts - Wnt2Wnt4and Wnt6 - that function locally in escort cells to vip escorts reno oogenesis. Whether and how local functions of these Wnts are regulated remains unknown.
Here we show that the dlp overexpression phenotype is multifaceted and phenocopies multiple Wnt loss-of-function phenotypes. Each aspect of dlp overexpression phenotype private escorts palmerston north suppressed by co-expression of individual Wntsand the suppression pattern exhibited by each Wnt suggests that Wnts escorts edison functional specificity in the germarium.
Further, dlp knockdown phenocopies Wnt gain-of-function phenotypes.
Together these data show that Dlp inhibits the functions of each Wnt. Our indicate that Dlp modulates the cincinnati independent escort of multiple extracellular Wnts for local paracrine Wnt aling in the germarium. Download PDF Download.
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Abstract Cells in multicellular organisms rely on secreted ligands for development and morphogenesis. Keywords Wnts.
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